Instructions:
Purified water preparation system can effect
pharmaceutical water directly.
it submits to GMP critical system.
RO and EDI equipment are designed for application in a wide range of purified
water preparation of pharmaceutical plant and core equipment.
Reverse osmosis is also called opposite osmosis relative to “osmosis”.
Osmosis is a process of water from the dilute solution flows to concentrate
through the semipermeable membrane automatically.
For the reverse osmosis , in the action of applied pressure ,water from the
concentrate flows to the dilute solution , it is UN-optionala.
EDI is also called continuous electro deionization , it brings electro dialysis
and ion exchange technology together as one, By the action of electric field ,
ion directional movement then removes the salts . The working of EDI also a
process of resin rebirth continuously ,EDI device is after RO system.
Using RO + EDI , water quality can reach16MΩ•CM, no any acid and alkali ,
work automatically for full process.
RO and EDI Features:
Water
quality is good , conductivity can reach 16MΩ•CM.
Degree
of stability for water quality is optimal.
Can
produce ultra-purified water complying with use`s requirement continuously.
Modularization
, full automatic control.
No
need rebirth of acid and alkali , no sewage drain.
Operate
simply , low labor strength.
Can
not stop machine for rebirth.
No
rebrith equipment and chemical storage and transportation.
Structure
of equipment is compact , little location.
Running
and maintenance cost is low.
Control system: to meet the user different control requirements , using PLC automatic control technology.
SINOPHAM experienced in purified water equipment for several years , such as :
argon protection automatic orbit welding , electro chemical polish, FAT plant ,
can assure quality stable and credible .
Modularization Design：
Modularization design is the guiding ideology for whole system , assemble RO ,
EDI pre-treatment equipment , post treatment etc according to equipment
capacity and configuration . The method reduces time of working , improves
instillation and commissioning frequency at site .
Material:
Selecting for GMP requirements and customer
cost budgeting basing on client requirements , such as pre-treatment , RO , EDI
, material of post treatment .
Linkage with storage tank and mode of recycle
production
For RO+EDI , controlled by the level of purified
water storage tank , in order to reduce biological deposit on the membrane ,
system always in the mode of production and recycle .
Softening agent for pre-treatment
Not add ant chemical in the process of
production , not use scale-inhibitor .
Two sets of pre-treatment
On the basis of customer requirements , to
guarantee RO and EDI production continuously , equip with two sets of
pre-treatment.
RO components
To keep stable and credible quality , using
hydranautics or DOW components .
It is better to use hot sterilization type RO components suggested by SINOPHAM,
the RO components can bear pasteurization , not use chemical in the production
, cleaning and sterilization
EDI Module:
EDI module made by America IONPURE or Electropure.
Hot water sterilization module is preferred , can sterilized by hot water .
Combination with hot sterilization RO components as a whole purified water
preparation system no need chemical completely .
Pump & Valves :
Pump and valves are frequent mobile components
, so need match with products . The common brands : Grundfos , Burket , GEMU,
Alfa Laval etc.
Crucial instruments and automatic control
According to different technical protocol ,
select different instrument and control configurations.
PLC and HMI are the common control mode , equipping with conductivity meter ,
temperature meter , flow meter , pressure meter etc. the function as following
:
To set and display techincs parameter .
Pre-treatment system work , backwash operation and control .
operation and control of RO unit
Operation and control of EDI
Operation and control of high temperature sterilization system.
Linkage with storage tank sensor.
Display and treatment of alarm : level high and low alarm of feed water and
soft water tank , flow high and low alarm of permeated water and concentrate
EDI , conductivity high alarm of permeated water RO , conductivity high alarm
of water output EDI .
Pipeline Preparation
Making use of argon protection automatic
orbit welding , the welding process is the implementation of mature welding
process . Welding technics evaluation prior to welding , record the parameter
during the welding process .
Polishing And Passivation
For the products , treated by mechanical
polishing , electro-polishing , passivation and measure & record for
roughness after treatment according to the requirements of ASME BPE and ISPE
guidance in the GMP .
Trial and Validation
Same as other products produced by SINOPHAM, provide the trial and validation service for system on the basis of guide of ISPE, including DQ, IQ , PQ,FAT, SAT etc .
