SPF600 Hard Capsule Glue Sealing Machine

SPF600 Hard Capsule Glue Sealing Machine Instructions: The Following is the study and description for the application of the liquid filling hard capsule sealing technology and the impact of capsule sealing technology on drug stability. Capsule sealing refers to packing a layer or multi-layer coating film in the capsule packet nested place after the empty capsule is filled with drugs, thus forming a sealing strip thin film layer. Internationally, the researches on capsule sealing technology have lasted for decades. The original purpose to seal capsule is to separate capsule. If the capsules are not sealed, they easy to be apart and possible to be counterfeited or poisoned by people, making the drug safety hard to be guaranteed. At present, the capsule sealing technology has drawn wide attention in the international community, and the American Pharmacopoeia (USP31-NF26) has listed in the appendix the suggestion to seal all hard capsule. At the same time, in the process of storage, transport and use, some drugs are easy to volatile, oxidize, and absorb moisture, and may degrade because of the influence of humidity and oxygen in the air. The adoption of the capsule sealing technology can make the capsule in sealed condition and reduce the exchange of air and moisture between the inside and the outside of the capsule shell. In this way, the access of the inside drug with water and oxygen is reduced, thus reducing the possible degradation of easily oxidative and hydrolyzed drugs and enhancing the stability of drugs. The traditional capsule is usually divided into two categories, i.e., the hard capsule (used for filling powder drugs) and the soft capsule (suitable for fish oil, vitamin A, vitamin E and other liquid medicines).  In recent years, the abroad drug manufactures have introduced the liquid hard capsule filling technology (to fill hard capsule with semi-solid, oily liquid, etc). Among them, there is a novel “completely transparent liquid capsule”. Liquid capsule technology provides a simple and effective way to develop drugs and health products. At the same time, this technology is still in constant development . There are three advantages for sealing capsule: 1. It can enhance the stability of drugs. After the hard capsule is filled with drugs, it is vulnerable to degrade because of the influence of humidity and oxygen in the air in the process of storage, transport and use. In this case, the question must be solved that how to improve the drug stability after packing in the pharmaceutical production and transport, operation and use process. After the drug is encapsulated in capsule, to seal the packet nested place of the capsule can prevent air in and out of the protective membrane. In this way, the above problem can be effectively solved. 2. It can prevent the inside volatile drug from volatilizing. Another application of hard capsule sealing is to avoid the failure phenomenon caused by the volatilization of the inside volatile drug. However, such a problem cannot be solved simply by the outer packing. After the drug is encapsulated into hard capsule, to seal the package nested place of capsule can effectively prevent the volatilization of drugs, so as to improve the inner quality of drugs. The limonene capsule is such an example. 3. Another advantage is anti-counterfeiting. In order to prevent brand or capsule of new products are faked, the capsule sealing technology can be used. The filling hard capsule production process is easy, so it is easy to be faked. But the seal is a patent technology. After adopting the sealing technology, it is less likely to be faked. In the United States, many clients use the sealing equipment with complying with the rules for OTC products. According to the client and 21. CFR 211.32 (Abstract #92 N-0314), all OTC products must have anti-counterfeit marking in the capsule. The application of the sealing technology: sealing technology is not only applied in health and nutrition capsule, but also in the medicine, in which it shows its great performance. 1. Be applied in the characteristic liquid products (expanding the concentration of blood drug) 2. Cover objectionable odors 3. Avoid the leakage of greasy or semi solid contents 4. Avoid double-blind trial needing opening capsules containing powder used as inhalant 5. Avoid the oxidation of effective components in capsule 6. Be enable hard gelatin capsules be chosen as soft gelatin capsules 7. Be in accordance with the food and drug regulation in the OTC market   Features: It is of touch screen control, Multi-system integrated and its degree of automation is higher; Material-lacking overload is under automatic protection which can ensure materials’ smooth supply; Sizing treatment is even and secondary sizing treatment technology locks sealing effect; Capsule’s baiting, orientation and in-place are accurate and speed can be controlled; It adopts highly-sensitive temperature sensor, by which, temperature of glue box can be real-time controlled; Glue box adopts asbestos heat insulation for design, by which, operations are safe and reliable; It adopts precision pneumatic control system which ensures glue box’s working smoothly up and down and forward and backward; Glue box and machine body adopt separating and closing design, by which, it can be easily disassembled and easily cleaned; Its originally created function of capsule chain plate positive and negative conveying can effectively extend conveying distance; It adopts reciprocating conveying mechanism, it can be naturally dried which does not affect drug properties inside capsule; Its part contacted with drug is manufactured fully by stainless steel which conforms to GMP standard.   Technical Parameters: Model SPF600 Capsule Specification 00#,0#,1#,2#,3#,4# Production Capacity ≤ 40, 000 Granules/Hour (Water-soluble Sealing Materials) ≤ 50, 000 Granules/Hour (Non-water-soluble Sealing materials) Temperature of water-soluble glue solution 30-40 centigrade Environmental requirements 25 centigrade and humidity of 45-75% Power 220V,50Hz, 2Kw Packing Size 2100 * 720 * 1680 mm Packing Weight 1200 Kg