Purified water preparation system can effect
pharmaceutical water directly.
it submits to GMP critical system.
RO and EDI equipment are designed for application in a wide range of purified water preparation of pharmaceutical plant and core equipment.
Reverse osmosis is also called opposite osmosis relative to “osmosis”.
Osmosis is a process of water from the dilute solution flows to concentrate through the semipermeable membrane automatically.
For the reverse osmosis , in the action of applied pressure ,water from the concentrate flows to the dilute solution , it is UN-optionala.
EDI is also called continuous electro deionization , it brings electro dialysis and ion exchange technology together as one, By the action of electric field , ion directional movement then removes the salts . The working of EDI also a process of resin rebirth continuously ,EDI device is after RO system.
Using RO + EDI , water quality can reach16MΩ•CM, no any acid and alkali , work automatically for full process.
RO and EDI Features:
Water quality is good , conductivity can reach 16MΩ•CM.
Degree of stability for water quality is optimal.
Can produce ultra-purified water complying with use`s requirement continuously.
Modularization , full automatic control.
No need rebirth of acid and alkali , no sewage drain.
Operate simply , low labor strength.
Can not stop machine for rebirth.
No rebrith equipment and chemical storage and transportation.
Structure of equipment is compact , little location.
Running and maintenance cost is low.
Control system: to meet the user different control requirements , using PLC automatic control technology.
SINOPHAM experienced in purified water equipment for several years , such as : argon protection automatic orbit welding , electro chemical polish, FAT plant , can assure quality stable and credible .
Modularization design is the guiding ideology for whole system , assemble RO , EDI pre-treatment equipment , post treatment etc according to equipment capacity and configuration . The method reduces time of working , improves instillation and commissioning frequency at site .
Selecting for GMP requirements and customer cost budgeting basing on client requirements , such as pre-treatment , RO , EDI , material of post treatment .
Linkage with storage tank and mode of recycle production
For RO+EDI , controlled by the level of purified water storage tank , in order to reduce biological deposit on the membrane , system always in the mode of production and recycle .
Softening agent for pre-treatment
Not add ant chemical in the process of production , not use scale-inhibitor .
Two sets of pre-treatment
On the basis of customer requirements , to guarantee RO and EDI production continuously , equip with two sets of pre-treatment.
To keep stable and credible quality , using
hydranautics or DOW components .
It is better to use hot sterilization type RO components suggested by SINOPHAM, the RO components can bear pasteurization , not use chemical in the production , cleaning and sterilization
EDI module made by America IONPURE or Electropure.
Hot water sterilization module is preferred , can sterilized by hot water . Combination with hot sterilization RO components as a whole purified water preparation system no need chemical completely .
Pump & Valves :
Pump and valves are frequent mobile components , so need match with products . The common brands : Grundfos , Burket , GEMU, Alfa Laval etc.
Crucial instruments and automatic control
According to different technical protocol ,
select different instrument and control configurations.
PLC and HMI are the common control mode , equipping with conductivity meter , temperature meter , flow meter , pressure meter etc. the function as following :
To set and display techincs parameter .
Pre-treatment system work , backwash operation and control .
operation and control of RO unit
Operation and control of EDI
Operation and control of high temperature sterilization system.
Linkage with storage tank sensor.
Display and treatment of alarm : level high and low alarm of feed water and soft water tank , flow high and low alarm of permeated water and concentrate EDI , conductivity high alarm of permeated water RO , conductivity high alarm of water output EDI .
Making use of argon protection automatic orbit welding , the welding process is the implementation of mature welding process . Welding technics evaluation prior to welding , record the parameter during the welding process .
Polishing And Passivation
For the products , treated by mechanical polishing , electro-polishing , passivation and measure & record for roughness after treatment according to the requirements of ASME BPE and ISPE guidance in the GMP .
Trial and Validation
Same as other products produced by SINOPHAM, provide the trial and validation service for system on the basis of guide of ISPE, including DQ, IQ , PQ,FAT, SAT etc .